Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy

association of angiotensin converting enzyme (ace) gene polymorphism and diabetic nephropathy

angiotensin i-converting enzyme (ace) gene polymorphism; genotype dd or d allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (dn). we examined the frequency of ace gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in tehran, iran. dna was extracted from the white blood cells and the i/d polymorphism of the ...

polymorphism in the angiotensin-converting enzyme (ace) gene and ace activity in type 2 diabetic patients

diabetes mellitus is a multifactorial disease. it has recently been shown that an insertion (i)/deletion (d) polymorphism exists in the angiotensin-converting enzyme (ace) gene that can affect the serum ace level. there are three genotypes: dd, di, and ii, with the ace level being highest in dd, intermediate in di, and lowest in ii. in the present investigation, 170 patients with type 2 diabete...

Angiotensin-converting enzyme inhibition and diabetic nephropathy.

Hypertension and diabetes mellitus are strongly associated conditions from epidemiologic, genetic, and pathophysiologic points of view. The prevalence of hypertension is high in patients with diabetes, and, conversely, many patients with essential hypertension are glucose intolerant. Proteinuria appears in 40-50% of patients with insulin-dependent diabetes mellitus and 20-30% of patients with n...

Angiotensin Converting Enzyme (ace) Gene Insertion Deletion Polymorphism and Its Association with Type 2 Diabetic Nephropathy

Proteinuria and angiotensin converting enzyme (ACE) gene polymorphism.

INTRODUCTION Although proteinuria is traditionally regarded as the result of glomerular damage, recent evidence suggests that proteinuria can directly cause renal damage through lysosomal injury, growth factor induced tubular fibrosis and transcriptase genes which trigger vasoactive and inflammatory renal damage. The renin angiotensin system which releases angiotensin, a most powerful vasoconst...